Study of thr role of afferent C fibers and cholinegic never endings in acute joint inflammation induced by Kaolin in rabbit

inflammatory  disease such as rheumatiod artheritis increase blood flow to joints.kaolin is one of substances injected into the joints in order to induce experimental acute joint inflammation the aim of this study was to determine the role played by nervous system in this model of acute in flammation.in the rabbit.evans blue technique was used to assess articular inflammation.the results indicated that :1)maximum inflammation accured after 4 hours of 4% kaolin injection,and after this period the intensity of the inflammation was reduced.2) injection of capssacine and substance P antagonist inside the join reduced the inflammation response by 39% and 15% respectively.therefore it can be suggested that afferent Cfibers may play a major in flammation process induced by kaolin,and substance P can be the mediator of the inflammation .in order to determine the role of sympathocholinergic fibers in this inflammation model,sulfate atropin was used locally.injection of this substance did not show a significant effect on inflammation response induced by kaolin.therefore sympathocholinergic system dose not seem to be involved in this model acute inflammation.